vinyl chloride exposure

Vinyl chloride … In 2007, the International Agency for Research on Cancer established the association of VCM with hepatocellular carcinoma (HCC), though o … Portal hypertension, liver fibrosis, and angiosarcoma of the liver (ASL) have been reported among workers exposed to vinyl chloride monomer (VCM) since the 1970s. Polyvinyl chloride, also known as PVC or vinyl, is arguably one of the most toxic types of plastic in our lives. A copy of the physician's statement shall be provided each employee. Exposure Sources of Vinyl Chloride. Vinyl chloride exposure has been shown to increase the risk of a rare form of liver cancer called angiosarcoma. Under the authority of the Federal Advisory Committee Act (FACA) P.L. Acute Exposure Guideline Levels. Acute (short-term) exposure to high levels of vinyl chloride in air has resulted in central nervous system (CNS) effects, such as … Studies in workers who inhale vinyl chloride over many years show an increased risk of … The U.S. Environmental Protection Agency has set a maximum contaminant level of 2 ppb of vinyl chloride for public drinking water supplies. Primary exposure to vinyl chloride occurs through inhalation. This fact sheet discusses possible health risks from exposure to low levels of vinyl chloride typically found in drinking water wells. Vinyl Chloride 75-01-4 _____ Hazard Summary . Sloane K. Tilley, Rebecca C. Fry, in Systems Biology in Toxicology and Environmental Health, 2015. References: cancer.gov, OSHA, IARC, CDC (1,2) Assessing Personal Exposure Vinyl chloride can be detected in urine and body tissues, but the tests are not reliable indicators of total exposure. It is not stable at high temperatures. Do standards exist for exposure to vinyl chloride? The odds ratio (OR) for ever exposure to vinyl chloride was 1.05 (95% confidence interval, CI: 0.68-1.62) and a modest, non-significant increase in the risk of lung cancer was found in the highest exposed subgroup. Most vinyl chloride is used to make polyvinyl chloride (PVC) plastic and vinyl products. Vinyl chloride is classified as Group 1 carcinogen by the IARC, meaning it is seen as a definite cause of cancer in humans. Final AEGLs for Vinyl chloride (75-01-4) Exposure Period AEGL-1 AEGL-2 AEGL-3; 10 minutes: 450 ppm : 2800 ppm : 12000 ppm : 30 minutes: 310 ppm : 1600 ppm : 6800 ppm : 60 minutes: 250 ppm : 1200 ppm : 4800 ppm : 4 hours: 140 ppm : 820 ppm : 3400 ppm : 8 hours: 70 ppm : 820 ppm : 3400 ppm Vinyl chloride is a synthetic, colorless gas. Angiosarcoma attacks the lining of blood vessels, and can occur in any area of the body. Vinyl Chloride 1. Prolonged exposure can cause cancer in the liver, brain, blood and lungs. Occupational exposure to vinyl chloride may occur in those workers concerned with the production, use, transport, storage, and disposal of the chemical. 5. It burns easily. September 2015 Vinyl Chloride What is vinyl chloride? If vinyl chloride is detected in your water, contact your local or state health department. A statement of each employee's suitability for continued exposure to vinyl chloride including use of protective equipment and respirators, shall be obtained from the examining physician promptly after any examination. PREFACE. One reason why PVC is so toxic is that it is often mixed with softening chemicals called plasticizers, the most well known variety being phalates. (1,2) Has been shown to increase the risk of … vinyl chloride … K.. Of cancer in humans _____ Hazard Summary chloride exposure has been shown increase... Found in drinking water supplies Systems Biology in Toxicology and Environmental health, 2015 detected in vinyl chloride exposure. 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